國立政治大學心理學系108-2學術研討會
講者：范揚騰 博士 (Center for Bioinformatics Research, National Chiao Tung University, Taiwan)
講題：Sensory matters: Revisiting Autism Spectrum Conditions through social neuroscience
時間：2020年5月21日（星期四）14：10-16：00
地點：政大果夫樓一樓101會議室
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摘要
Aberrant sensory features have been reported in the very first descriptions of autism spectrum conditions (ASC), and it is estimated to occur in up to 90% of ASC individuals. Acknowledging this, “hyper-or–hypo-reactivity to sensory input or unusual interests in sensory aspects of the environment” is now included in the diagnostic criteria for the condition. Notably, ASC is known to be heritable; however, very few studies, particularly in neurobiological research, have investigated whether atypical sensory responsivity is manifested in relatives of ASC. Such endophenotype-based research can provide valuable insights into the genetic underpinnings of ASC and help disentangle the nature of sensory features in ASC. This study, therefore, was aimed to examine sensory responsivity in individuals with ASC, matched controls (CON), and their parents (parents of children with ASC (P-ASC) and those of CON children (P-CON)) by combining the questionnaire- and lab-based sensory evaluations with fMRI measurements. Behaviorally, ASC and P-ASC exhibited higher levels of sensory responsivity and more unpleasant feelings to sensory stimuli than CON and P-CON, respectively. Significant agreements were only obtained within ASC dyads for sensory responsivity. At the neuronal level, ASC and P-ASC displayed greater activations in the primary sensory cortical areas relative to CON and P-CON, respectively. The overlapping activations further were obtained in these sensory areas in ASC and the P-ASC groups. Importantly, sensory-evoked activation in the superior frontal gyrus within the P-ASC group was a significant moderator in the relationship between sensory symptoms and unpleasantness of sensory stimuli. These results converge on the notion that ASC and their unaffected parents share similar neurobehavioral patterns of sensory features, and provide a guide for early detection of ASC and, ultimately, to targeted ASC interventions.
講者簡介
Education
1. Ph.D., Institute of Neuroscience, National Yang-Ming University, Taiwan
2. M.S., Institute of Clinical Behavioral Science, Chang Gung University, Taiwan
3. B.S., Department of Occupational Therapy, Chung Shan Medicine University, Taiwan
Jobs
1. Assistant research fellow, Center for Bioinformatics Research, National Chiao Tung University, Taiwan
2. Postdoctoral research fellow, Department of Sociology, National Chengchi University, Taiwan
3. Postdoctoral research fellow, School of Occupational Therapy, College of Medicine, National Taiwan University, Taiwan
