:::

最新消息

:::

活動與演講
  • 標題:演講公告-2018.12.27(四)黃鈺婷博士
  • 公告日期:2018-12-20

國立政治大學心理學系107-1學術研討會

講者:黃鈺婷 博士(政治大學心理學系)

講題:The acute effects of dopaminergic medication and deep brain stimulation of subthalamic nucleus on basic executive functions including shifting, updating and inhibition in Parkinson’s disease patients 

時間:20181227日(星期四)1410-1600

地點:政大果夫樓一樓101會議室

敬邀各位師生踴躍參加!!

 

演講摘要:

The general aim of my PhD thesis was to investigate the effects of two common treatments of Parkinson’s disease (PD), dopamine medication and deep brain stimulation (DBS) of the subthalamic nucleus (STN), on executive functions (EFs) including the abilities of shifting, updating and inhibition in patients relative to age- matched healthy controls. The thesis consisted of four studies. Study 1 examined the acute effect of dopamine medication on PD patients who had been previously diagnosed with impulsive control disorders (ICDs) using a moving dots paradigm to assess their abilities of context monitoring. Study 2 created predictive models using behavioural data from the previous studies to build classification predictive models, to demonstrate that behavioural patterns on a moving dots task could potentially be used as a screening tool in predicting vulnerability to develop ICDs in PD patients. Study 3 examined the acute effects of STN DBS on task switching using a moving dots paradigm in PD patients. Study 4 investigated the acute effects of STN DBS on reprogramming actions when encountering surprising events, using a probabilistic reaction time (RT) task. It was hypothesised that for both treatments, being ON states would induce impaired executive functions that lead to faster RTs and more incorrect responses in PD patients, due to the ‘dopamine overdose hypothesis’ and the DBS interrupting the role of the STN in inhibitory control. In summary, the acute manipulation of both treatments did not render significantly negative effects on PD patients behaviourally. However, PD patients still showed certain difference on task performance compared to age-matched healthy controls, which may shed lights on the role of basal ganglia in basic abilities of EFs. Furthermore, the behavioural patterns on tasks involving core aspects of EFs may potentially be used to predict the onset of ICDs, which provides benefits to clinical purpose.

 

講者簡介

黃鈺婷博士為政治大學心理學系大學部系友。2012年於政大畢業後在廖瑞銘教授主導之生理心理學實驗室擔任專任助理。後分別於2014年及2018年在倫敦大學學院(University College London, UCL)獲得其認知神經科學碩士及博士學位。其碩士成績榮獲該校認知神經科學所(Institute of Cognitive Neuroscience, ICNShallice Prize 殊榮。碩士畢業後,黃博士在以深度腦部刺激(Deep Brain Stimulation, DBS)治療動作相關疾患而聞名之UCL 神經內科研究所(Institute of Neurology, IoN)的功能性神經外科單位(Unit of Functional Neurosurgery)中,從事藥物治療與DBS 對於帕金森氏病人(Parkinsons disease)認知及執行功能可能帶來的影響之研究。黃博士目前擔任國立政治大學心智、大腦與學習研究中心全人計畫之博士後研究員,負責決策與基因相關研究。

  • 附件檔案:
  • 參考連結:
  • 張貼人:溫宜錦
  • 最後修改時間:2018-12-20 PM 5:06

cron web_use_log